RESUMO
Assembly line efficiency is one of the most important parameters that determine the overall efficiency of a manufacturing company. The production of a product under optimum conditions is ensured by a balanced assembly. With a balanced assembly line, machinery, material and labour costs are reduced. Within the scope of this research, real data about the daily production capacity and assembly line efficiency of a company producing Emergency Luminaire were taken, the same assembly line was balanced with 4 different Heuristic ALB methods and the results were compared. According to the results obtained, a high line efficiency of 93.955% was achieved using the Hoffman, Comsoal and Moodie&Young (M&Y) methods, and 84.414% was achieved with the Ranked Positional Weight (RPW) method. As a result of this, it was observed that the daily production capacity increased from 250 units to 375 units. As a result of the study, it was revealed that the efficiency of the existing assembly line and accordingly the daily production capacity increased. In addition, the study results of this assembly line were taught to an artificial neural network model for training purposes, and the work station results of the operations of a different assembly line were obtained with 99.940 accuracy. In this context, it has been revealed that the artificial neural networks method can be used in addition to the use of the heuristic method in the solution of ALB problems.
RESUMO
El síndrome de Netherton (SN) es una enfermedad autosómica recesiva, muy poco frecuente, que se caracteriza por la presencia de eritrodermia ictiosiforme congènita, anomalías capilares y manifestaciones atópicas. Este síndrome es consecuencia de una mutación recesiva en el gen SPINK5. Las manifestaciones del síndrome de SN varían considerablemente entre las personas que lo padecen. Aquí informamos el caso de un recién nacido que presentaba insuficiencia respiratoria grave, hipotermia y eritrodermia, al que se le diagnosticó SN, confirmado mediante pruebas genéticas moleculares.
Netherton syndrome (NS) is a rare, autosomal recessive disease characterized with congenital ichthyosiform erythroderma, hair abnormality and atopic manifestations. This syndrome is caused by recessive mutation in the SPINK5 gene. Disease manifestations vary considerably among NS individuals. We report a newborn presented with severe respiratory insufficiency, hypothermia and erythroderma, was diagnosed as having NS and confirmed with molecular genetic testing.
Assuntos
Humanos , Masculino , Recém-Nascido , Insuficiência Respiratória/etiologia , Eritrodermia Ictiosiforme Congênita/etiologia , Síndrome de Netherton/diagnóstico , Insuficiência Respiratória/genética , Eritrodermia Ictiosiforme Congênita/genética , Síndrome de Netherton/genética , Inibidor de Serinopeptidase do Tipo Kazal 5/genética , Hipotermia/etiologia , Hipotermia/genética , MutaçãoRESUMO
Netherton syndrome (NS) is a rare, autosomal recessive disease characterized with congenital ichthyosiform erythroderma, hair abnormality and atopic manifestations. This syndrome is caused by recessive mutation in the SPINK5 gene. Disease manifestations vary considerably among NS individuals. We report a newborn presented with severe respiratory insufficiency, hypothermia and erythroderma, was diagnosed as having NS and confirmed with molecular genetic testing.
El síndrome de Netherton (SN) es una enfermedad autosómica recesiva, muy poco frecuente, que se caracteriza por la presencia de eritrodermia ictiosiforme congénita, anomalías capilares y manifestaciones atópicas. Este síndrome es consecuencia de una mutación recesiva en el gen SPINK5. Las manifestaciones del síndrome de SN varían considerablemente entre las personas que lo padecen. Aquí informamos el caso de un recién nacido que presentaba insuficiencia respiratoria grave, hipotermia y eritrodermia, al que se le diagnosticó SN, confirmado mediante pruebas genéticas moleculares.
